Value Proposition:
· Technology is a liquid embolic agent
· Provides a solution to adhesion and lack of control of embolic agent release during therapeutic embolization
· Has applications in procedures including aneurysm clippings and drug delivery
Unmet Need
Therapeutic embolization is the intentional endovascular occlusion of an artery or vein to stop or prevent excessive bleeding. The procedure is done to eliminate atypical connections between blood vessels, close off blood vessels feeding tumors, or stop excessive bleeding. Liquid embolic agents are one embolic agent used in therapeutic embolization and include glues and alcohol agents. However, these agents have significant challenges including possible adhesion of the delivery agent and limited control over embolic agent release. Therefore, there is a strong need for a liquid embolic agent with non-adhesive properties and the ability to selectively control embolic agent release.
Technology Description
Researchers at Johns Hopkins have developed a biocompatible polymer for intravascular and extravascular use. The technology, EmboGel, can be injected for use as a therapeutic material for clinical procedures. The technology can be used as a standalone embolic agent, a bulking material for plastic and reconstructive procedures, or as a transport vector for bioactive agents. These bioactive agents include chemotherapies, anti-inflammatory agents, antimicrobial drugs, hormonal therapy agents, and adenovirus for gene therapies. Additionally, EmboGel is a non-adhesive agent which reduces the risk of microcatheter tip retention and is radiopaque. EmboGel can be selectively dissolved with EmboClear into a biocompatible liquid.
Stage of Development
· In vivo studies in rabbits have been completed.
· The inventors are seeking licensing partners to commercialize this technology.
Publication
Barnett BP, Gailloud P. Assessment of EmboGel--a selectively dissolvable radiopaque hydrogel for embolic applications. J Vasc Interv Radiol. 2011 Feb;22(2):203-11. doi: 10.1016/j.jvir.2010.10.010. Epub 2010 Dec 23. PMID: 21185201.
