Alternative Splice Variant Patterns of Human Telomerase Reverse Transcriptase (hTERT) in Thyroid Tumors Distinguish Benign from Malignant
Disclosure Date:
7/10/2006
C05018: Alternative Splice Variant Patterns of Human Telomerase Reverse Transcriptase (hTERT) in Thyroid Tumors Distinguish Benign from Malignant Technical Details: Human telomerase reverse transcriptase (hTERT) is activated in thyroid cancer. Despite this, its usefulness as a marker in the distinction of benign from malignant neoplasm has not been proven. hTERT is known to have several deletion isoforms or alternative splice variants in addition to its full length isoform: a-, ß-, a-ß-, and r-deletions. JHU scientists now report a difference in hTERT alternative splice variant patterns between benign and malignant thyroid tumors as well as demonstrate the feasibility of testing these differences in thyroid fine needle aspiration (FNA) biopsies. Furthermore, they also demonstrate that c-myc gene expression is associated with the gene expression of 4 hTERT isoforms.
Looking for Partners: Differences in hTERT alternative splice variant gene expression patterns can distinguish benign from malignant thyroid tumors. This could be applied to all cancer types. Furthermore, more detailed knowledge of hTERT alternative splice variant patterns has powerful implications for understanding and treating cancer.
Publications/Associated Cases: Wang, Y., Kowalski, J., Tsai, H. -., Marik, R., Prasad, N., Somervell, H., et al. (2008). Differentiating alternative splice variant patterns of human telomerase reverse transcriptase in thyroid neoplasms. Thyroid, 18(10), 1055-1063. Retrieved from www.scopus.com
Zeiger, M. A., Smallridge, R. C., Clark, D. P., Liang, C. -., Carty, S. E., Watson, C. G., et al. (1999). Human telomerase reverse transcriptase (hTERT) gene expression in FNA samples from thyroid neoplasms. Surgery, 126(6), 1195-1199. Retrieved from www.scopus.com
Saji, M., Xydas, S., Westra, W. H., Liang, C. -., Clark, D. P., Udelsman, R., et al. (1999). Human telomerase reverse transcriptase (hTERT) gene expression in thyroid neoplasms. Clinical Cancer Research, 5(6), 1483-1489. Retrieved from www.scopus.com
Patent Information:
| Title |
App Type |
Country |
Serial No. |
Patent No. |
File Date |
Issued Date |
Expire Date |
Patent Status |
| Alternative Splice Variant Patterns of Human Telomerase Reverse Transcriptase (hTERT) in Thyroid Tumors to Distinguish Benign from Malignant |
PCT: Patent Cooperation Treaty |
United States |
12/746,418 |
9,222,136 |
6/4/2010 |
12/29/2015 |
8/20/2030 |
Granted |
| Alternative Splice Variant Patterns of Human Telomerase Reverse Transcriptase (hTERT) in Thyroid Tumors to Distinguish Benign from Malignant |
CON: Continuation |
United States |
15/719,815 |
10,774,389 |
9/29/2017 |
9/15/2020 |
12/5/2028 |
Granted |
|
|
Inventors:
Category(s):
Clinical and Disease Specializations, Clinical and Disease Specializations > Endocrinology, Clinical and Disease Specializations > Oncology > Thyroid Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology,
Get custom alerts for techs in these categories/from these inventors:
|
