Technical Details:
MicroRNAs (miRNAs) are 18-24 nucleotide RNA molecules that regulate the stability or translational efficiency of target mRNAs. miRNAs are frequently dysregulated in cancer cells and can act as oncogenes and tumor-suppressors. The proto-oncogene c-MYC encodes a transcription factor that regulates cell proliferation, growth, and apoptosis. Dysregulated expression or function of c-Myc is one of the most common abnormalities in human malignancy. The MYC cancer gene increases the expression of a cluster of miRNAs that are implicated in the development of human cancers. Scientists at JHU and the University of Pennsylvania have now demonstrated that the MYC-activated miRNAs promote angiogenesis and thus promote tumor growth
Looking for Partners:
These microRNAs represent a novel class of targets for anti-angiogenesis therapies.
Publications:
Nature Genetics - 38, 1060 - 1065 (2006); US 9,255,267; and US 8,466,117
