MicroRNAs As Targets for Anti-Angiogenic Therapies

Case ID:

C05032

C05032: MicroRNAs As Targets for Anti-Angiogenic Therapies
Technical Details:
MicroRNAs (miRNAs) are 18-24 nucleotide RNA molecules that regulate the stability or translational efficiency of target mRNAs. miRNAs are frequently dysregulated in cancer cells and can act as oncogenes and tumor-suppressors. The proto-oncogene c-MYC encodes a transcription factor that regulates cell proliferation, growth, and apoptosis. Dysregulated expression or function of c-Myc is one of the most common abnormalities in human malignancy. The MYC cancer gene increases the expression of a cluster of miRNAs that are implicated in the development of human cancers. Scientists at JHU and the University of Pennsylvania have now demonstrated that the MYC-activated miRNAs promote angiogenesis and thus promote tumor growth
Looking for Partners:
These microRNAs represent a novel class of targets for anti-angiogenesis therapies.
Publications:
Nature Genetics - 38, 1060 - 1065 (2006); US 9,255,267; and US 8,466,117

Patent Information:

Title	App Type	Country	Serial No.	Patent No.	File Date	Issued Date	Expire Date	Patent Status
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster	PCT: Patent Cooperation Treaty	United States	12/309,788	8,466,117	3/15/2010	6/18/2013	7/28/2027	Granted
Compositions and Methods for Modulating Angiogenesis	CON: Continuation	United States	13/919,417	9,255,267	6/17/2013	2/9/2016	7/30/2027	Granted

Direct Link:

https://jhu.technologypublisher.com/technology/16478

Inventors:

Category(s):

Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools > Nucleic Acids,

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For Information, Contact:

Michael Woods

mwoods19@jh.edu

410-614-0300

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