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Inhibition of Transplantation Rejection By Suppressing HVEM
Case ID:
C05085
Report of Invention:
10/10/2006
Web Published:
10/7/2014
C05085: Inhibition of Transplantation Rejection By Suppressing HVEM
Technical Details:
Decoy lymphotoxin beta receptor (LT? has potent immune inhibitory activities, and thus represents a promising biologic for the treatment of inflammation, autoimmune diseases and graft-versus-host disease (GVHD). As this reagent interrupts multiple molecular interactions, including LT?T?and LIGHT-HVEM/LT? underlying molecular mechanisms have yet to be fully understood. Scientists at JHU have now determined that blockade of the LIGHT-HVEM pathway is sufficient to induce amelioration of GVHD in mouse models and illustrate a novel target for selective immunotherapy in allogeneic bone marrow transplantation.
Looking for Partners:
GVHD is a common complication of allogeneic bone marrow transplantation and both acute and chronic forms remain difficult to treat. The novel mechanism of GVHD elucidated in the invention described will serve as a target for therapeutic intervention.
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Direct Link:
https://jhu.technologypublisher.com/technology/16498
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Category(s):
Clinical and Disease Specializations, Clinical and Disease Specializations > Transplantation > Bone Marrow Transplant, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Transplantation,
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For Information, Contact:
Jeanine Pennington
jpennin5@jhmi.edu
410-614-0300
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