C05140: Novel Peptide and Protein Modulators of AngiogenesisNovelty:
Identification of families of angiogenesis modulating peptides and development of computational screening methods for the same.
Value Proposition:
The invention features a list of protein families and certain isolated peptides which have been found to possess angiogenesis modulating properties by means of a bioinformatics based approach. Other advantages include:
• Identification of novel proteins which have not been associated with angiogenesis modulating.
• Proteins can be explored as novel drug discovery and development targets.
• Proteins could be used to generate monoclonal anti-bodies with anti-angiogenic potential.
• The methods can be used to develop angiogenesis microarrays.
Technical Details:
Johns Hopkins researchers have identified protein families, certain isolated peptides and their corresponding analogs with putative angiogenesis modulating properties by developing a bioinformatics based computational screening method for identifying such peptides. The peptide motifs of interest belong to the thrombospondin, CXC chemokine, collagen, somatotropin and serpin motifs.
Looking for Partners:
To develop & commercialize the technology as a pharmaceutical composition for treatment of cancer by angiogenesis inhibition
Stage of Development:
Discovery
Data Availability:
Under CDA / NDA
Publications/Associated Cases:
C10753 , C04835 , C11348 , C11389
