Development of a Combinational Paradigm Combating HIV, HIV/HSV or HIV/HPV Infections in Humans

Case ID:
C05144

 

Technical Details:

WHO report has stated that there are 39.5 million people currently HIV positive worldwide. Of these, 4.3 million have been infected in the year 2006 alone. AIDS death reached 2.9 million this year which is the highest ever reported in any year. There are 40,000 new AIDS cases a year in U.S. along. The anti-HIV compounds that are currently being used to treat AIDS patients include several reverse transcriptase inhibitors. However, these drugs gradually lose their effectiveness with the appearance of a group of populated viral mutants. Thus, development of alternative therapeutic methods that inhibit HIV infections and protect host cell mediated immunity (CMI) is urgently needed. JHU scientists have found that several plant compounds can block HIV-1 production in culture CD4 + cells synergistically against a variety of HIV strains. They are equally active in targeting mutant strains that are highly resistant to currently available drugs against HIV protease and reverse transcriptase as compared to the wild type viruses.

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This technology can be used to control AIDS epidemics.

 

Publications:

US Issued Patent 9,005,889

US Issued Patent 9,259,433


Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Combinational Paradigm Combating HIV, HIV/HSV or HIV/HPV Infections in Humans Using Small Molecular Weight Compounds from Plants PCT: Patent Cooperation Treaty United States 12/523,513 9,005,889 1/27/2010 4/14/2015 1/16/2028 Granted
Combinational Paradigm Combating HIV, HIV/HSV or HIV/HPV Infections in Humans Using Small Molecular Weight Compounds from Plants DIV: Divisional United States 14/641,727 9,259,433 3/9/2015 2/16/2016 3/9/2035 Granted
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For Information, Contact:
Nakisha Holder
nickki@jhu.edu
410-614-0300
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