C10346: X-ray CT Apparatus and Myocardial Blood Flow Amount Image Display SystemNovelty:
A method of deriving myocardial blood flow (MBF) from CT imaging.
Value Proposition:
At the present time, quantitative myocardial perfusion imaging requires serial imaging of contrast kinetics over time. Serial imaging increases the X-ray exposure to patients and thus the radiation dose. This method derives contrast kinetics, individualized to each patient, from bolus tracking and CT data. To date, no methods have been developed to derive quantitative myocardial blood flow information from helical multi-detector computed tomography (MDCT) images. This method provides quantification of myocardial perfusion. The invention includes software developed to implement this new method. This new method reduces X-ray exposure and thus overall radiation dose. It has the following advantages:
• Can derive MBF from MDCT with less radiation exposure
• Helical-derived quantifiers of MBF correlate with current measures of flow
• Ability to distinguish between stenotic and remote territories under adenosine stress
Technical Details:
Johns Hopkins researchers have developed a novel method of deriving quantitative myocardial blood flow measurements from helical MDCT image data sets. Specifically, the invention can: 1) calculate the first-order transfer constants extraction fraction, and permeability-surface area product; and 2) based on the results obtained by dynamic MDCT perfusion, develop a quantitative analytic method that derives Myocardial Blood Flow (MBF) measurements from time-registered helical MDCT image data. A look-up table with extraction fraction correction can be used to accurately convert Ki to the absolute MBF. The MBF obtained using the combination of bolus tracking and time-registered helical myocardial perfusion CT correlates well with the microsphere MBF. The proposed helical myocardial perfusion CT method shows promise for the quantification of regional MBF.
Looking for Partners:
To develop and commercialize the technology as a method for determining MBF.
Stage of Development:
Pre-clinical
Data Availability:
Under CDA/NDA
Publications/Associated Cases:
Associated case: C11290
