C10552: Hybridoma Secreting Anti-Excitatory Amino Acid Transporter 2 (EAAT2) AntibodyNovelty:
Hybridoma cell line that secretes monoclonal antibody to GLT1/EAAT2 protein.
Value Proposition:
Mutations or decreased expression of the GLT1/EAAT2 protein are associated with amyotrophic lateral sclerosis and thus the detection of protein can be used as an effective diagnostic approach. This invention is a hybridoma that produces monoclonal antibody specific to GLT1/ EAAT2. Additional advantages include:
• Detects expression of GLT1/EAAT2 in both human and mice
• Can be used to screen for potential therapies for amyotrophic lateral sclerosis
• Detection works both in cell lysate and tissue sample
Technical Details:
Johns Hopkins researchers have generated hybridoma clone 6 in mouse which secretes the IgG monoclonal antibody specific to the membrane-bound transporter protein GLT1/EAAT2. The GLT1/EAAT2 is a central nervous system transporter responsible for the clearance of glutamate for proper synaptic activation. The antibody specifically recognizes the C-terminal peptide of the transporter in cell lysate by Western blot analysis and in tissue by immunostaining.
Looking for Partners:
To license the technology for internal research use.
Stage of Development:
Ready for Use
Data Availability:
Under CDA / NDA
Publications/Associated Cases:
Not available at this time
