Technical Details:
Malaria is severe disease and caused by a parasite called Plasmodium. According to the World Health Organization, there were 247 million malaria cases and nearly a million deaths in 2006. Key intervention to control malaria is prompt and effective treatment with first step of good and reliable diagnostic testing. Hybridoma clone 299-2 HRPII 4A5 producing the monoclonal antibodies that are specific to an abundant malaria protein called histidine rich protein 2 specific to Plasmodium falciparum.
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The antibody can be used for diagnostic testing or immunohistochemical detection of the malaria parasite.
Publications/Associated Cases:
Lee N, et al (2006) Effect of sequence variation in Plasmodium falciparum histidine- rich protein 2 on binding of specific monoclonal antibodies: Implications for rapid diagnostic tests for malaria. J Clin Microbiol. 44(8): 2773-2778.
