This monoclonal antibody specifically binds to Glutamate Receptor 2-phosphoserine-880.
Technical Details:
Glutamate receptors (GluR) mediate excitatory synaptic transmission in the central nervous system and are critical for most neuronal processes, including synaptic plasticity, neuronal development, and several neurological and psychiatric disorders. AMPA receptors are major receptors in neurons at glutamatergic synapses. Recent studies have demonstrated that AMPA receptor function can be rapidly regulated during several forms of synaptic plasticity. AMPA receptors are complexes of four subunits known as GluR1, GluR2, GluR3 and GluR4. The C-terminal tails of AMPA receptor subunits associate with molecules in neurons via protein sequence areas termed PDZ domains. The serine within the C-terminal PDZ ligand of the GluR2 and GluR3 subunits may be a potential phosphorylation site to regulate AMPA receptor binding to PDZ domains. Regulation of GluR2 interaction with PDZ domain-containing proteins by phosphorylation may modulate surface expression of AMPA receptors during synaptic plasticity (Chung et al).
Looking for Partners:
These monoclonal antibodies could be used as neuroscience research tool.
