These are rabbit polyclonal antibodies directed against the rodent proteins neuropilin-1 and neuropilin-2. The neuropilins are semaphorin receptors.
Technical Details:
The semaphorin family contains a large number of phylogenetically conserved proteins and includes several members that have been shown to function in repulsive axon guidance. Semaphorin III (Sema III) is a secreted protein that in vitro causes neuronal growth cone collapse and chemorepulsion of neurites, and in vivo is required for correct sensory afferent innervation and other aspects of development. The mechanism of Sema III function, however, is unknown. Neuropilin, a type I transmembrane protein implicated in aspects of neurodevelopment, is a Sema III receptor. Neuropilin-2 has been identified and is a related neuropilin family member. Neuropilin-2 is a receptor for the secreted semaphorin IV (Sema IV) and acts selectively to mediate repulsive guidance events in discrete populations of neurons. neuropilin-2 and semaIV are expressed in strikingly complementary patterns during neurodevelopment. Neuropilin and neuropilin-2 are expressed in overlapping, yet distinct, populations of neurons in the rat embryonic nervous system. Lastly, neuropilin-1 can homomultimerize and form heteromultimers with neuropilin-2. These results provide insight into how interactions between neuropilins and secreted semaphorins function to coordinate repulsive axon guidance during neurodevelopment.
Looking for Partners:
This antibody technology could be commercialized as a research tool. The antibodies are useful for biochemical, histological and function blocking purposes for study of neurodevelopment.
