C10751: Phosphospecific LRRK2 Antibodies to Monitor Activation State of LRRK2
Value Proposition:
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are responsible for late-onset autosomal dominant Parkinson's disease (PD). LRRK2 may have roles in pathogenesis of several neurodegenerative disorders. Inventors have produced antibodies that can be used to monitor auto-phosphorylation and activation of LRRK2. These antibodies are specific for phosphorylated LRRK2 identified as anti-pT2031; anti-pS2032 and anti-pT2035.
Looking for Partners:
This technology can be commercialized as a research tool for the study of neurological function and neurodegenerative disorders such as Parkinson’s disease. Specifically they can be used to monitor auto-phophorylation and activation of Leucine rich repeat kinase 2 (LRRK2).
