Conditional Human Alpha-synuclein Transgenic Mice

C10787: Conditional Human Alpha-synuclein Transgenic Mice – Parkinson’s Disease Model
Value Proposition:
These mice may provide insights about differential, cell type selective neuronal vulnerability in Parkinson’s Disease.
Technical Details:
Mutations or increased copy numbers of alpha-synuclein gene cause Parkinson’s Disease (PD) in some humans. To better understand how these mutations cause PD, JHU scientists have developed transgenic mouse line harboring wild type and A53T mutant human alpha-synuclein with and without C-terminal truncations.
Looking for Partners:
The mice can be used for preclinical testing of novel therapies for Parkinson’s Disease, including but not limited to inhibitors of alpha-synuclein aggregation.

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