Conditional Human LRRK2 Transgenic Mice

Case ID:

C10788

C10788: Conditional Human LRRK2 Transgenic Mice - Parkinson’s Disease Model

Value Proposition:

These mice may provide insights about differential, cell type selective neuronal vulnerability in Parkinson’s Disease.

Technical Details:

Mutations in gene encoding LRRK2 are known to cause Parkinson’s Disease (PD) in some humans. To better understand how these mutations cause Parkinson’s Disease, JHU scientists have developed transgenic mouse line harboring Gly to Ser changes in codon 2019 of human LRRK2 cDNA.

Looking for Partners:

This mice can be used:

• for preclinical testing of novel therapies for PD, including LRRK2 inhibitors.

• to identify and/or validate new therapeutic targets for PD, including LRRK2 substrates.

• to better understand neurodegenerative mechanisms relevant to PD via cell biological, neuropathological, geneomic, proteomic, and other studies, resulting in new therapeutic approaches.

Direct Link:

https://jhu.technologypublisher.com/technology/16764

Inventors:

Category(s):

Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools,

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For Information, Contact:

Christine Joseph

cjoseph6@jhmi.edu

410-614-0300

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