Shielding Methods to Reduce Power Deposition in Tissue Exposed to Radio-frequency Electromagnetic Fields

Case ID:
C10911

C10911: Targeted radiation- and chemo-enhancing heat therapy for cancer

Novelty:

The proposed technology is a device and platform for treating local and metastatic cancer using multifunctionalized iron oxide nanoparticles in conjunction with radiation and chemotherapeutic agents.

Value Proposition:

Metastatic cancer is persistent and difficult to treat, but studies have shown that heat between 39 °C and 49 °C sensitizes metastatic cells to radiation and chemotherapy. This invention uses coated iron oxide nanoparticles capable of localizing in cancer cells to induce hyperthermia when exposed to low-power and non-injurious alternating magnetic field generated by a device that incorporates the features of both solenoid and Helmholtz coils. The suspended nanoparticles offer contrast with both magnetic resonance imaging (MRI) and x-ray, facilitating image guided treatment of cancer through targeted delivery of both heat and chemotherapeutic (or radio-therapeutic) agent(s) to the diseased tissue. To prevent damage to healthy tissue, this technology includes a shielding method for both active cooling and protection from power deposition. Key advantages of this technology include:

• Precision of therapeutic delivery with finer control of dose-deposition
• Effective pain relief and delayed disease progression
• Improved therapeutic outcomes
• Image-guided monitoring of treatment and patient follow-up
• Delivery of chemotherapeutic drugs along with the nanoparticles to the tumor is possible
• Protection of healthy tissue allows targeted treatment over a large region of interest
• Data from animal models of metastatic cancer show safe delivery and treatment without systemic concentration of nanoparticles
• Our nanoparticle formulation produces therapeutic heat at much lower AMF power levels than any currently available iron oxide nanoparticle formulation, without sacrificing MRI contrast capability

Stage of Development:

Preclinical

Data Availability:

Under CDA/NDA

Publications/Associated Cases:

Cases related to summary: C11865 C11199 C11494

Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
SYSTEMS AND METHODS TO REDUCE POWER DEPOSITION IN TISSUE EXPOSED TO RADIO FREQUENCY ELECTROMAGNETIC FIELDS PCT: Patent Cooperation Treaty United States 13/503,520 9,333,369 6/22/2012 5/10/2016 10/22/2030 Granted
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For Information, Contact:
Vera Sampels
vsampel2@jhu.edu
410-614-0300
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