Mammalian Anti-apoptotic Gene Promotes Stress Tolerance in Green Microalgae for Increased Cell Viability and Biomass Production During Cultivation

Case ID:
C10920
Disclosure Date:
10/28/2009

C10920: Genetically Engineered Algae to Increase Cell Viability and Biomass Production

Value Proposition:

• Increases cell viability and biomass production.
• High-level expression of recombinant proteins.
• Addresses a major need in new biofuel sources.
• Proprietary constructs are available.

Technical Details:

In certain cases of large-scale algal cultivation, microalgae meet their demise as a result of high irradiance and/or nutrient limitation by means of programmed cell death (PCD). Using proprietary constructs, JHU scientists have genetically engineered microalgae to increase cell viability and biomass production during cultivation. The enhanced microalgae are completely protected from photo-oxidative stress that reduces wild-type cell growth as much as 75%. While similar methods have been used for biotechnological purposes to produce plants that resist disease, this feat has never before been achieved in microalgae.

Looking for Partners:

Improved efficiency of large-scale cultivation of microalgae for production of microalgal biomass, nutraceuticals, biofuel metabolites, recombinant proteins



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For Information, Contact:
Nakisha Holder
nickki@jhu.edu
410-614-0300
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