Technical Details:
The Vac-CRT/E7 vaccine can be employed to deliver chimeric CRT/E7 gene into the host cells in order to generate potent E7-specific CD8+ T cell immune responses and antitumor effects against E7- expressing tumors.
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Cervical cancer vaccine
Publications:
1. Hsieh CJ, Kim TW, Hung CF, Juang J, Moniz M, Boyd DA, He L, Chen PJ, Chen CH, Wu TC. Enhancement of vaccinia vaccine potency by linkage of tumor antigen gene to gene encoding calreticulin. Vaccine. 2004 Sep 28;22(29-30):3993-4001
