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Novel Inhibitors of Protein Kinase Signaling that are Neuroprotective and have Potential Applicability for the Treatment of Glaucoma, Optic Nerve Disease, and other Forms of Neurodegeneration
Case ID:
C10938
Report of Invention:
11/20/2009
Web Published:
10/7/2014
Glaucoma is a major cause of visual loss and blindness in elderly Americans and throughout the world. One approach to treatment of glaucoma, and other optic nerve diseases as well as other neurodegenerations, is to develop “neuroprotective” agents that promote the survival of neurons. We have synthesized and tested a number of novel compounds, based on structural similarity to known protein kinase inhibitors, that can promote the survival and/or neurite outgrowth of retinal ganglion cells (RGCs), the cells in the retina that die in glaucoma and whose loss leads to vision loss. Based on the activity of these compounds on RGCs, one or more of them may also be relevant for the treatment of other optic nerve diseases and other diseases, including but not limited to the neurodegenerative diseases, in which there is loss of neurons.
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
COMPOSITIONS AND METHODS FOR TREATMENT OF NEURODEGENERATIVE DISEASE
PCT: Patent Cooperation Treaty
United States
13/636,415
9,162,981
5/9/2013
10/20/2015
3/23/2031
Granted
COMPOSITIONS AND METHODS FOR TREATMENT OF NEURODEGENERATIVE DISEASE
CON: Continuation
United States
14/886,938
9,539,239
10/19/2015
1/10/2017
3/23/2031
Granted
Direct Link:
https://jhu.technologypublisher.com/technology/16792
Inventors:
Category(s):
Clinical and Disease Specializations, Clinical and Disease Specializations > Ophthalmology > Glaucoma, Clinical and Disease Specializations > Ophthalmology > Optic Neuropathy, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Ophthalmology,
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For Information, Contact:
Vera Sampels
vsampel2@jhu.edu
410-614-0300
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