Clinically Relevant Tissue Specific Fluorescent Metastatic Human Breast Cancer Cell Lines

Case ID:

C10939

Disclosure Date:

11/20/2009

C10939: Clinically Relevant Tissue Specific Fluorescent Metastatic Human Breast Cancer Cell Lines

Value Proposition:

• Overcomes several inherent shortcomings of present breast cancer xenograft model systems.

• Provides definitive clinical models of human breast cancer in mice that are comparable to the human disease by accurately recapitulating the human disease from the primary tumor site to metastasis at distant organ sites.

• Allows to discern the progression of breast cancer dissemination from the primary site to early micro-metastatic lesions at the tissue and organ reported for the human disease.

• The in vivo drug testing can be unambiguously tracked in real-time in live animals and at post mortem in whole animal and tissue preparations using the inherent fluorescence of the cells.

• Provides genomic, RNA and protein signature resources for the study of genetic changes and all cellular pathways that function in the promotion of metastatic disease to the different sites from which they were recovered.

Technical Details:

The pan-metastatic and specific tissue seeking metastatic human breast cancer cell lines described here provide models of human breast cancer in mice that are comparable to the human disease by accurately recapitulating the human disease from the primary tumor site to metastasis at distant organ sites. We describe the first available human orthotopic breast cancer xenograft model system that provides the capability of tracking endogenous bone and brain metastasis progression in the manner.

Looking for Partners:

Evaluate drug efficacy

Direct Link:

https://jhu.technologypublisher.com/technology/16793

Inventors:

Category(s):

Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology,

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For Information, Contact:

Vera Sampels

vsampel2@jhu.edu

410-614-0300

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