C11071: High Quality Human Pluripotent Stem Cell (iPSC) Lines
Value Proposition: - High quality, clinically safe iPSCs that are more akin to hESC - 300 times more efficient for human cell types - Molecular signatures that are highly similar to hESC - Differentiate robustly to vascular, hematopoietic, neural, and cardiac lineages - Cell lines that lack malignant potential
Technical Details:
BACKGROUND
Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are thought to have the capacity to form any cell type in the body, a state described as pluripotency. Pluripotent stem cells can differentiate to one of three early lineages: ectoderm (which will form skin and brain), mesoderm (which will form heart and blood) and endoderm (which will form gut and lungs). The properties associated with iPSCs have important implications in cell therapy, drug discovery and developmental modeling. To date, the extremely high efficiencies of generating iPSC from hematopoietic progenitors in a transgenic mouse system that expressed integrated inducible constructs has not been duplicated in human target cell types. TECHNOLOGY JHU inventors have generated clinically safe patient-specific human pluripotent stem cells lines that lack malignant potential. The cell lines are CD34-CB-iPSC Lines (lines 6.2, 19.11).
Looking for Partners:
Cell lines for use in research associated with cell therapy, drug discovery and developmental modeling.
