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Smo Deficient Embryonic Fibroblast Cell Line_Smo4-/-
Case ID:
C11093
Report of Invention:
4/23/2010
Web Published:
10/7/2014
C11093: Sonic hedgehog-responsive cell line that lacks functional Smoothened protein
Technical Details:
The material is a Sonic hedgehog-responsive cell line that lacks functional Smoothened protein. Smoothened is a major target of antineoplastic agents, which gives the cell line the commercial utility.
Looking for Partners:
The cell line can be used to test Smoothened function or to generate a mouse cell line that expresses only the human version of the Smoothened protein for drug screening.
Publications/Associated Cases:
Ma Y, et al (2002) Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell. 2002 Oct 4;111(1):63-75.
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Direct Link:
https://jhu.technologypublisher.com/technology/16832
Inventors:
Category(s):
Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools,
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For Information, Contact:
Nakisha Holder
nickki@jhu.edu
410-614-0300
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