Technical Details:
The material is a Sonic hedgehog-responsive cell line that lacks functional Smoothened protein. Smoothened is a major target of antineoplastic agents, which gives the cell line the commercial utility.
Looking for Partners:
The cell line can be used to test Smoothened function or to generate a mouse cell line that expresses only the human version of the Smoothened protein for drug screening.
Publications/Associated Cases:
Ma Y, et al (2002) Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell. 2002 Oct 4;111(1):63-75.
