C11103: A Novel Sublingual Film for the Treatment of Allergy
Value Proposition:
JHU inventors have developed a mucoadhesive film containing a quantity of allergen to be placed under the tongue for the purpose of reducing adverse reactions to allergens by immunotherapy.
ADVANTAGES:
- A mucoadhesive film held under the tongue for immunotherapy addresses the recognized challenge of treating children who find it hard to hold drops under the tongue without swallowing.
- The film can also be flavored and colored for better patient compliance.
- It is easier to standardize, removing any need for measuring at the physician's office and allowing for a simplified dosing schedule.
- The film fabrication process is simple and versatile, and it can easily be extended to employ antigens for treating a variety of allergies, such as peanut, tree nuts, milk, cockroach. It can also contain immunotherapy adjuvants to stimulate immunotherapy response.
- Thin film composition shows longer term stability compared to other formulations. This technology offers several additional advantages including the ease of modulating the allergen dose, release rate adjustment, standardization, administration and mass deployment.
Technical Details:
The prevalence of food allergies has increased dramatically in the past two decades. Food allergies negatively affect quality of life and put patients at risk for life-threatening allergic reactions. One way to reduce the risk of these reactions is by sublingual immunotherapy. So far, this therapy has been limited by maximum dose and can prove cumbersome. Alternate methods of immunotherapy administration are clearly desirable to improve efficacy and patient compliance.
Looking for Partners:
This technology can potentially be commercialized as a thin film immunotherapy composition, as well as a method of making the thin film composition comprising allergens.
Publications: US20150125495
