Published as Zhang et al. The AAA(+) ATPase Thorase Regulates AMPA Receptor-Dependent Synaptic Plasticity and Behavior. Cell. 2011. Apr 15;145(2):284-99.
Technical Details:
Many millions of people battle chronic neurological conditions and diseases worldwide. This discovery will help understand processes of long-term potentiation (LTP) and long-term depression (LTD) of neuronal activity and will prove to be an indispensible tool in the research for major cellular mechanisms that underlies learning and memory.
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This transgenic mouse model could be used as a research tool for neurodegenerative dieases and disorders.
