C11364: Schizophrenia Associated Induced Pluripotent Stem Cell LinesNovelty:
Induced Pluripotent Stem Cell (iPSC) lines derived from somatic cells from members of an American family with schizophrenia and without a schizophrenia diagnosis
Value Proposition:
Mutations in the Disrupted-in-Schizophrenia 1 (DISC1) gene have been shown to predispose individuals to psychiatric disorders like schizophrenia. This technology is the establishment of multiple iPS cell lines with or without the DISC1 mutation associated with schizophrenia to screen for drugs against schizophrenia and other psychiatric disorders. Additional advantages include:
• Rare cell lines from an American family with DISC1 mutations different from the Scottish family cells in which DISC1 was identified
• Can be used in the study of bipolar disorder and major depression
• iPSC cells derived from same family group without DISC1 mutation very useful as assay control
Technical Details:
Johns Hopkins researchers have generated iPSCs that are derived from skin fibroblast cells taken from multiple members of an American family with schizophrenia and depression. Multiple control iPS cell lines were derived from family members without a DISC1 mutation, and multiple iPS cell lines containing a DISC1 mutation were derived from the members of the same family. This iPSC line collection includes control and test cell lines and could potentially be used to model human mental disorders.
Looking for Partners:
To develop & commercialize the technology as a research tool to study mental disorders associated with the DISC1 gene mutation and to screen drugs against those psychiatric diseases.
Stage of Development:
Multiple Cell lines established
Data Availability:
Data validated
Publications/Associated Cases:
Mol Psychiatry. 2011 Apr;16(4):358-60
C11860
