CUG Expressing tg Mice

C11471: Junctophilin 3 (JPH3) Transgenic Mice Expressing Consecutive CUG Triplets
Value Proposition:
These transgenic mouse models express a short untranslatable fragment of exon 2A of the gene junctophilin 3 (JPH3) containing either 10 or 100 consecutive CUG triplets in the brain. Relevant publication: Rudnicki et al. Huntington's disease-like 2 is associated with CUG repeat-containing RNA foci. Ann Neurol. 2007 Mar;61(3):272-82.
Technical Details:
Huntington's disease like 2 (HDL2) is a progressive, adult-onset neurodegenerative disorder characterized clinically by irregular involuntary movements, muscle rigidity, slowed motion, psychiatric syndromes, dementia, and death. To date there is no cure for Huntington's diseases. There is an urgent unmet medical need for effective research tools to learn more about neurodegenerative diseases.
Looking for Partners:
These mice would be useful research tools for the study of Huntington's disease and potentially other neurodegenerative conditions.

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