C11505: Method for Obtaining Multi-probe Magnetic Resonance Images (MRI)Novelty:
A novel method of obtaining simultaneous detection of multiple probes within an MRI, allowing for a visual representation of the data that can be separated based on probes.
Value Proposition:
Current MRI technology would significantly benefit from having the ability to discriminate probes during data acquisition, creating an opportunity for the separation of these probes based on a variety of MRI data characteristics. This technology creates this capability by incorporating an additional step of performing a chemical exchange saturation transfer (CEST) or magnetization transfer (MT) magnetic labeling experiment of a subject using an MRI machine. This additional step allows visualization of probes through saturation pulse variation, measuring a multitude of characteristics, creating an opportunity to acquire incredibly vital information that can be used to determine more accurate and informative medical diagnosis. Post processing of the data acquired creates a visual representation of the data that can then be further analyzed and separated by probe characteristic. Additional advantages include:
• Simple method which yields substantially more useful data
• CEST probes have been designed to label many important factors including viral particles, peptides, drug delivery particles, changes in temperature, changes in pH, and metabolite concentrations
• Application to many disease states including separation of cancerous tumor tissue and characterization of acute ischemia
Technical Details:
Johns Hopkins researchers have developed CEST contrast through the application of a radiofrequency saturation pulse at the resonance frequency of the exchangeable protons, essentially creating a loss in signal, leading to a yield of contrast. This technology proposes using CEST probes and obtaining MRI data by imparting a saturation pulses in a way that single or multiple frequencies are obtained simultaneously. A data process unit will receive the set of data and with post-processing, a highly informative and analytical visual representation can be developed for more effective diagnosis and imaging using MRI.
Looking for Partners:
To develop & commercialize the technology as a novel and more informative method of MRI imaging.
Stage of Development:
Pre-Clinical
Data Availability:
Animal Data available
Publications/Associated Cases:
Magn Reson Med. 2012 Oct;68(4):1074-86
