Ethoxyquin and Derivatives for Treatment of Peripheral Neuropathies and Other Neurodegenerative Disorders

Case ID:

C11605

Peripheral neuropathies are a group of neurodegenerative disorders affecting the peripheral nerves. Currently there is no effective therapy that prevents nerve degeneration except in cases of autoimmune peripheral neuropathies. Wehave now identified a compound, ethoxyquin (EQ), that prevents nerve degeneration in chemotherapy-induced peripheral neuropathy (CIPN), diabetic peripheral neuropathy (DPN) and human immunodeficiency associated sensory neuropathy (HIV-SN). Novel derivatives of ethoxyquin retain their neuroprotective efficacy in models of both CIPN and HIV-SN. Evaluation of efficacy of EQ in other neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) is ongoing.

Patent Information:

Title	App Type	Country	Serial No.	Patent No.	File Date	Issued Date	Expire Date	Patent Status
Compounds for Treatment of Peripheral Neuropathy and Other Neurodegenerative Disorders	PCT: Patent Cooperation Treaty	United States	14/127,326	9,527,817	6/17/2014	12/27/2016	6/21/2032	Granted

Direct Link:

https://jhu.technologypublisher.com/technology/16992

Inventors:

Category(s):

Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Neuropathy, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities,

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For Information, Contact:

Heather Curran

hpretty2@jhu.edu

410-614-0300

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