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Ethoxyquin and Derivatives for Treatment of Peripheral Neuropathies and Other Neurodegenerative Disorders
Case ID:
C11605
Report of Invention:
6/19/2011
Web Published:
10/7/2014
Peripheral neuropathies are a group of neurodegenerative disorders affecting the peripheral nerves. Currently there is no effective therapy that prevents nerve degeneration except in cases of autoimmune peripheral neuropathies. Wehave now identified a compound, ethoxyquin (EQ), that prevents nerve degeneration in chemotherapy-induced peripheral neuropathy (CIPN), diabetic peripheral neuropathy (DPN) and human immunodeficiency associated sensory neuropathy (HIV-SN). Novel derivatives of ethoxyquin retain their neuroprotective efficacy in models of both CIPN and HIV-SN. Evaluation of efficacy of EQ in other neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) is ongoing.
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
Compounds for Treatment of Peripheral Neuropathy and Other Neurodegenerative Disorders
PCT: Patent Cooperation Treaty
United States
14/127,326
9,527,817
6/17/2014
12/27/2016
6/21/2032
Granted
Direct Link:
https://jhu.technologypublisher.com/technology/16992
Inventors:
Category(s):
Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Neuropathy, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities,
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For Information, Contact:
Heather Curran
hpretty2@jhu.edu
410-614-0300
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