C11626: Transgenic Mice with the Oncoprotein YAP
Novelty:
Transgenic mice that can reversibly express the oncoprotein YAP (Yes-Associated Protein).
Value Proposition:
The oncoprotein YAP controls cell proliferation and apoptosis and has been shown to be overexpressed in different types of cancer. This invention is a transgenic mouse line that can selectively express YAP using tissue-specific Tet-On or Tet-Off system. Other advantages include:
• Inducible and tissue-specific expression
• Reversible gene expression
• Can be coexpressed with other oncogenes to decipher cancer pathways
• Cancer study without impairing normal cells
Technical Details:
Johns Hopkins researchers have generated inducible TRE-YAP transgenic mice. In this strain, human YAP protein expression can be controlled by the antibody tetracycline (TE) in tissue-specific manner depending on the type of transactivator TE (tTE) or repressor TE (rtTE) strain being used. Furthermore, this mouse line can be crossbred with other TRE lines to co-express YAP and other proteins involved in the Hippo tumor-suppressor signaling pathway. This aids in developing efficient therapeutic treatments for cancer.
Looking for Partners:
To develop & commercialize the technology as a research tool to develop cancer therapy.
Stage of Development:
Mouse line established
Data Availability:
Animal data
Publications/Associated Cases:
Cell. 2007 September 21; 130(6): 11201133
Genes Dev. 2010 Nov 1; 24(21): 2383–2388.
