Novelty:
A mouse monoclonal antibody (mAb) against LAG-3 (Lymphocyte Activation Gene 3).
Value Proposition:
LAG-3 is expressed on the cell surface of activated T-cells and is known to be an important global regulatory molecule that controls many aspects of T-cell proliferation and homeostasis. This invention is an effective mouse LAG-3 monoclonal antibody that can easily identify and locate the LAG-3 protein in the cell. This antibody may be useful in the study of T-cell activation or suppression in many diseases.
Technical Details:
Johns Hopkins and St. Jude researchers have developed a new mAb against D3/D4 domains of LAG-3. The specificity of the purified antibody was validated in Lag3-/- T cells.
Looking for Partners:
To develop & commercialize the technology as a research tool to study T-lymphocytes.
Stage of Development:
Ready for use
Data Availability:
Validated Data
Publications/Associated Cases:
Eur J Immunol. 2010 Jun;40(6):1768-77
