C11773: Library of Genotype 1 Hepatitis C Virus particlesNovelty:
This technology consists of a wide range of human genotype 1 hepatitis C viral (HCV-1) particles, which can be used for research and development of anti-HCV-1 therapies.
Value Proposition:
Availability of a library of HCV-1 viral particles provides a valuable resource for anti-HCV-1 drug and biologic development. The library of HCV-1 particles can be used to create multi-genotype targeting treatment and diagnostic options. Other advantages include:
• Can be used to evaluate extent of neutralizing antibody response to HCV-1 genotypes.
• Applications in vaccine efficacy, antibody development as well development of small molecule inhibitors.
• Potential use in determining mechanism of entry and replication of HCV-1.
Technical Details:
Johns Hopkins researchers have created an extensive library of HCV-1 pseudotyped viral particles (HCVpp) derived from viruses purified from human blood samples that represents the natural diversity of genotype 1 HCV sequences. HCVpp are replication incompetent HIV viral particles with HCV envelope proteins in place of the HIV envelope protein.
Looking for Partners:
To develop and commercialize the technology as a research tool to facilitate HCV-1 vaccine efficacy quantification and as a target for HCV-1 drug discovery and development.
Stage of Development:
Commercialization
Data Availability:
Under CDA / NDA
Publications/Associated Cases:
Not available at this time
