Novelty:
This invention allows for a higher temporal resolution for Chemical Exchange Saturation Transfer (CEST) imaging while preserving high contrast ratios.
Value Proposition:
CEST imaging allows for the detection of low concentrations of solutes. However, in order to do this type of imaging, a long saturation pulse is required. This new invention divides the long saturation pulse into 3-5 smaller pulses, after which an image can be acquired. The temporal resolution is increased over previous methods, and tumor contrast values are improved by 3-5%. Other advantages include:
Technical Details:
Johns Hopkins researchers have developed a method of acquiring and compiling CEST images during the saturation pulse. CEST imaging relies on proton exchange to provide contrast for MRI images, and has shown promise for grading brain tumors as well as evaluating ischemia. However, current methods suffer from low temporal efficiency. This new method, termed Multi-echo Length and Offset VARied Saturation (Me-LOVARS), allows for acquiring multiple images during each CEST pulse train, improving both temporal efficiency and contrast. Images are acquired at varied intervals during the pulse train and are later averaged to give a complete picture. This method can also be used to correct contrast maps against MTC, B0, B1 and to determine exchange rates. The images are acquired with a low flip-angle fast gradient echo read-out sequence.
Looking for Partners:
To develop and commercialize the technology as a new way of acquiring CEST MRI images.
Stage of Development:
Pre-Clinical
Data Availability:
Under CDA/NDA
Publications/Associated Cases:
Not at this time.
