Discovery of Novel Targets for Aberrant Methylation in Pancreatic Carcinoma Using High-throughput Microarrays

Case ID:

C04187

C04187: Discovery of Novel Targets for Aberrant Methylation in Pancreatic Carcinoma Using High-throughput Microarrays
Technical Details:
In order to identify potential targets for aberrant methylation in pancreatic cancer, we analyzed global changes in gene expression profiles of 4 pancreatic cancer cell lines after treatment with the demethylating agent 5-aza-2?-deoxycytidine (5Aza-dC) and/or the histone deacetylase inhibitor trichostatin A (TSA). A substantial number of genes were induced 5-fold or greater by 5Aza-dC alone, TSA alone, and by treatment with both agents. The methylation status of 11 of these genes was examined in a panel of 42 pancreatic cancers, and all 11 of these genes were aberrantly methylated in pancreatic cancer but rarely if any methylated in 10 normal pancreatic ductal epithelia.
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Cancer Diagnostics

Patent Information:

Title	App Type	Country	Serial No.	Patent No.	File Date	Issued Date	Expire Date	Patent Status
Aberrantly Methylated Genes in Pancreatic Cancer	PCT: Patent Cooperation Treaty	United States	10/548,976	7,485,418	6/23/2006	2/3/2009	3/17/2024	Granted
Aberrantly Methylated Genes in Pancreatic Cancer	DIV: Divisional	United States	12/351,709	8,785,614	1/9/2009	7/22/2014	3/17/2024	Granted

Direct Link:

https://jhu.technologypublisher.com/technology/18721

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Category(s):

Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > In Vitro Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools,

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For Information, Contact:

Michael Woods

mwoods19@jh.edu

410-614-0300

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