Discovery of Novel Targets for Aberrant Methylation in Pancreatic Carcinoma Using High-throughput Microarrays

Case ID:

C04187

Disclosure Date:

2/5/2003

C04187: Discovery of Novel Targets for Aberrant Methylation in Pancreatic Carcinoma Using High-throughput Microarrays
Technical Details:
In order to identify potential targets for aberrant methylation in pancreatic cancer, we analyzed global changes in gene expression profiles of 4 pancreatic cancer cell lines after treatment with the demethylating agent 5-aza-2?-deoxycytidine (5Aza-dC) and/or the histone deacetylase inhibitor trichostatin A (TSA). A substantial number of genes were induced 5-fold or greater by 5Aza-dC alone, TSA alone, and by treatment with both agents. The methylation status of 11 of these genes was examined in a panel of 42 pancreatic cancers, and all 11 of these genes were aberrantly methylated in pancreatic cancer but rarely if any methylated in 10 normal pancreatic ductal epithelia.
Looking for Partners:
Cancer Diagnostics

Patent Information:

Title	App Type	Country	Serial No.	Patent No.	File Date	Issued Date	Expire Date	Patent Status
Aberrantly Methylated Genes in Pancreatic Cancer	PCT: Patent Cooperation Treaty	United States	10/548,976	7,485,418	6/23/2006	2/3/2009	3/17/2024	Granted
Aberrantly Methylated Genes in Pancreatic Cancer	DIV: Divisional	United States	12/351,709	8,785,614	1/9/2009	7/22/2014	3/17/2024	Granted

Direct Link:

https://jhu.technologypublisher.com/technology/18721

Inventors:

Category(s):

Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > In Vitro Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools,

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For Information, Contact:

Anum Afzal

aafzal7@jhu.edu

410-614-0300

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