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Deconvolution and Selective Control of Specific Biological Activities with Partially Acylated and Mixed SCFA-derivatized Monosaccharide-SCFA Hybrid Molecules
Case ID:
C10074
Report of Invention:
5/22/2007
Web Published:
3/24/2015
Value Proposition:
This invention solves two problems inherent with the use of Short Chain Fatty Acid (SCFA)-monosaccharide hybrid molecules to modulate cellular activity. The first problem is the toxicity of former versions of these compounds. The current invention uses structure activity relationships as it has been discovered to either enhance or avoid toxicity (depending on the intended application). A second problem is that these compounds have a diverse set of biological activities and the current invention allows specific activities to be deconvoluted and selectively controlled; as a consequence better control can be gained over the biological responses elicited by these compounds. Two such applications described herein are control of stem cell differentiation and reduced invasiveness of cancer cells such as metastatic breast cancer cells.
Technical Details:
This invention comprises fatty acid carbohydrate-hydroxyl-hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.
Looking for Partners:
The compounds of the invention can be developed and commercialized as valuable targets for the development of carbohydrate based vaccine for cancer, influenza or HIV on the concept of glycoengineering and immunology. Additional compounds of the invention are applicable in the study of glycosylation of nuclear or cytosolic proteins, which contribute towards the design of drugs or vaccines for deadly disease like diabetes, or Parkinsons or Alzheimer's disease.
Patent Status:
Granted US Patents
8,916,544
and
9,067,960
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
HYBRID SCFA-HYDROXYL-DERIVATIZED MONOSACCHARIDES, METHODS OF SYNTHESIS, AND METHODS OF TREATING DISORDERS
PCT: Patent Cooperation Treaty
United States
12/671,994
8,916,544
5/13/2011
12/23/2014
10/11/2031
Granted
HYBRID SCFA-HYDROXYL-DERIVATIZED MONOSACCHARIDES, METHODS OF SYNTHESIS, AND METHODS OF TREATING DISORDERS
DIV: Divisional
United States
14/246,809
9,067,960
4/7/2014
6/30/2015
8/7/2028
Granted
Direct Link:
https://jhu.technologypublisher.com/technology/18728
Inventors:
Category(s):
Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities,
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For Information, Contact:
Vera Sampels
vsampel2@jhu.edu
410-614-0300
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