Chemically-induced mutant mouse line C3.B6-Erbb3::superscript-m3329Ddg::/J (aka C3.B6-Erbb3::superscript-I449S::/DdgJ )

C11344: Mouse strain with Erbb3 mutation to study nervous system development.

Mice is stored at The Jackson Laboratory (www.jax.org)

Jax Stock No. 013059 - C3.B6.-Erbb3^tm33292Ddg/J
Technical Details:

Erbb3 encodes a protein that belongs to the Epidermal Growth Factor Receptor (EGFR) family of receptor tyrosine kinases. ERBB3 is known to interact with Neuregulin 1 which is thought to be essential for the normal development of the nervous system and the heart. Inventor has disclosed a mouse line developed via N-ethyl-N-nitrosourea mutagenesis. This mouse strain is called C3.B6-Erbb3m3329Ddg/J (aka C3.B6-Erbb3I449S/DdgJ) and has a point mutation (T1346G) in exon 13 of Erbb3 that created a single amino acid substitution (I449S).

Looking for Partners:

The mouse strain is potentially commercializable as a research tool to further study nervous system development.

Publications/Associated Cases:

Merte et al. (2010) J Neurosci 30(16): 5767-5775.