C11345: Mouse strain for studying TrkA in neurons.
Mice is stored at The Jackson Laboratory (www.jax.org)
Jax Stock No. 013720 B6.l29S6(Cg)-Ntrkltm2Ddg/J
Technical Details:
Mouse models can make essential contributions to our understanding of the cause, prevention and treatment of disease. Inventor has disclosed a knock-in mutant mouse line that expresses a FLAG-TrkA fusion protein. TrkA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family.
Looking for Partners:
The mouse strain is potentially commercializable as a research tool which may be useful for visualization of expression, trafficking, and sorting of endogenous, post-endocytic TrkA in neurons.
Publications/Associated Cases:
Mandai K; Guo T; St Hillaire C; Meabon JS; Kanning KC; Bothwell M; Ginty DD. 2009. LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Neuron 63(5):614-27. [PubMed: 19755105]
Sharma N; Deppmann CD; Harrington AW; St. Hillaire C; Chen ZY, Lee FS; Ginty DD. 2010 Long-distance control of synapse assembly by target-derived NGF. Neuron 67(3): 422-34. [PubMed: 20696380]
