IRF-5 Flox Mice
JHU REF: C11759
Invention novelty: This tangible material is a genetically modified mouse strain IRF-5 flox. In this strain, loxP sites have been inserted into the second intron of the IRF-5 gene.
Value Proposition
- Mouse strain IRF-5 Flox
Technical Details
Johns Hopkins researchers have developed a genetically modified mouse strain IRF-5 flox. In this strain, loxP sites have been inserted into the second intron of the IRF-5 gene. The incorporation of the loxP sites, allow for excision of the genetic material that is between the loxP sites when exposed to Cre, a site specific recombinase enzyme. The result is inactivation of the IRF-5 gene. More specifically, when an IRF-5 flox mouse is crossbred with a Cre specific mouse strain, IRF-5 function can be inactivated or turned off in a tissue specific and/or temporal manner. The ability to selectively turn off a gene at a specific place an time is a tremendous tool for controlling gene expression and ultimately understanding how protein expression affects various pathways, systems, and disease.
IRF5 is a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. The IRF-5 flox mice are useful tools for the study of various disease indications including but not limited to autoimmune disease, innate immunity, inflammatory disease, and antiviral infection.
Looking for Partners: To license this material for research purposes.
Stage of Development: Tangible Material – Available through Jackson Labs Stock # 017311, Strain Name: C57BL/6-Irf5tm1Ppr/J
Data Availability: Animal data
Patent Status: None – Tangible Material
Publication(s)/Associated Cases: “Not at this time”
Categories: Research Tools, Tangible Property, Mouse strain
Keywords: IRF-5 Flox mice
