TITLE
A Transgenic Mouse Line for Ablating Cells Positive for Opn4 Expression
CASE NUMBER: C13013
ABSTRACT
Rod and cone photoreceptors detect light and relay this information through a multisynaptic pathway to the brain via retinal ganglion cells (RGCs). These retinal outputs support not only pattern vision, but also non-image forming (NIF) functions, which include circadian photoentrainment and pupillary light reflex (PLR). In mammals, NIF functions are mediated by rods, cones and the melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs). Rod/cone photoreceptors and ipRGCs are complementary in signalling light intensity for NIF functions. The ipRGCs, in addition to being directly photosensitive, also receive synaptic input from rod/cone networks. To determine how the ipRGCs relay rod/cone light information for both image and non-image forming functions, Dr. Hattar genetically ablated ipRGCs in mice.
FEATURES
Opn4aDTA/+
A transgenic mouse consisting of the placement of (aDTA) encoding attenuated diphtheria toxin A subunit (aDTA) at the Opn4 locus. As a way to ablate intrinsically photosensitive retinal ganglion cells (ipRGCs)..
STAGE OF DEVELOPMENT
Tangible material, Opn4aDTA/+ transgenic Mice
ASSOCIATED PUBLICATIONS
- PMC2871301 -
TECHNOLOGY CLASSIFICATION
Primary Category: Discovery/Research Tools
Primary Subcategory: In Vivo Research Tool
