TITLE
Opn4creERT2/+ Knock-in Mice
CASE NUMBER: C13015
ABSTRACT
Retinal ganglion cells (RGCs), the output neurons of the retina, have axons that project via the optic nerve to diverse targets in the brain. Typically, RGC axons do not branch before exiting the retina and thus do not provide it with synaptic feedback. Although a small subset of RGCs with intraretinal axon collaterals has been previously observed in human, monkey, cat, and turtle, their function remains unknown. A small, more recently identified population of RGCs expresses the photopigment melanopsin. These intrinsically photosensitive retinal ganglion cells (ipRGCs) transmit an irradiance-coding signal to visual nuclei in the brain, contributing both to image-forming vision and to several nonimage-forming functions, including circadian photoentrainment and the pupillary light reflex.
FEATURES
A transgenic mouse line consisting of:
Opn4-driven tamoxifen-inducible Cre knock in.
To study the axonal targeting of melanopsin cells in mouse.
STAGE OF DEVELOPMENT
Tangible material, Opn4creERT2/+ Knock-in Mice
ASSOCIATED PUBLICATIONS
- PMC4316817 -
TECHNOLOGY CLASSIFICATION
Primary Category: Discovery/Research Tools
Primary Subcategory: In Vivo Research Tool
