Invention novelty: This invention is ellipsoidal biomimetic particle with supported lipid bilayer (SLB) that mimic the most critical features of cell-cell interactions including paracrine release of soluble mediators, dynamic radius of curvature, and fluidity of surface receptors for clustering.
Value Proposition
There has been growing interest in the use of particles with supported lipid bilayers for multiple applications including drug delivery, gene delivery, and diagnostic imaging. To date, almost all of these particles have been made with spherical shapes. Johns Hopkins researchers have developed an anisotropic, ellipsoidal particle with a supported lipid bilayer to synergize the benefits of a biomimetic, fluidic surface of a supported lipid bilayer (SLB) with the benefits of a non-spherical particle. Other advantages are…
· The capability to resist macrophage phagocytosis
· Allow for more accurate mimicry of natural cells through the presentation of laterally mobile proteins on the surface of anisotropic biodegradable particles.
· The capability to evade non-specific uptake pathways
Technical Details
John Hopkins researchers have developed a procedure to reproducibly generate non-spherical, ellipsoidal SLB with a biodegradable polymer support. This technology is an anisotropic ellipsoidal micro or nanoparticle coated with a fluidic and functionalized lipid bilayer. It enables enhanced cellular mimicry.
Looking for Partners:
To develop and commercialize the technology as synthetic particles that mimic biological cells with applications in drug delivery, gene delivery and immunoengineering.
Publication(s)/Associated Cases: Acta Biomater. 2018 May; 72: 228–238.
