MUTANT MOUSE MODELS FOR NEURODEVELOPMENTAL RESEARCH
JHU REF: C12482
Invention novelty: This tangible material includes mouse models with mutant B3gnt1 and Ispd genes.
Value Proposition
Mouse strains with chemically-induced mutations of B3gnt1 and Ispd genes.
Technical Details
Johns Hopkins researchers have developed chemically altered mouse strain with mutations in B3gnt1 (b-1,3-N-acetyl glucosaminyltransferase-1) and Ispd genes (Isoprenoid synthase domain containing gene).These genes were identified to be the key regulators of axon guidance. In order to study the effect of these genes on neurodevelopmental disorders, chemical mutations were induced in mouse models, so as to obtain B3gnt1 and Ispd knock-out mice.
Looking for Partners: To license this material for research purposes
Stage of Development: Tangible Material
Data Availability: Animal data
Patent Status: None - Tangible material.
Publication(s)/Associated Cases: Neuron 76, 931–944, Dec 2012
