Linx Null Mouse Models
JHU REF: C12483
Invention novelty: This tangible material includes linx (Islr2) null mouse strain generated by the knock-in of targeted Gfp in the linx locus.
Value Proposition:
Linx mutant mouse strain.
Technical Details:
Johns Hopkins researchers have developed a linx null mouse strain. This was done in order to assess the in vivo function of Linx and its interactions with TrkA, TrkC, Ret,and p75NTR signaling during the development of PNS neurons and to visualize axons of Linx+ neurons. The linx mutant mouse was generated by the insertion of Tau- EGFP reporter gene into the exon coding the entire coding sequence of Linx
Looking for Partners: To license this material for research purposes
Stage of Development: Tangible Material
Data Availability: Animal data
Patent Status: None - Tangible material.
Publication(s)/Associated Cases: Neuron. 2009 Sep 10;63(5):614-27
Categories: Tangible material, research tool, mouse strain
Keywords: Linx-mutant mice, Tau-EGFP knock-in, Islr2
