MUTATIONS OF SEMA3A, SEC24B, AND MEGF8 IN MOUSE MODELS
JHU REF: C12484
Invention novelty:
This tangible material includes a mutant strain of mice produced by inducing chemical mutations of SEMA3A, SEC24B and MEGf8 mutations in mouse models.
Value Proposition
Sema3a point mutant mice
Sec24b point mutant mice
Megf8L1775P point mutant mouse
Technical Details
Johns Hopkins researchers have developed a strain of mice by chemically induced mutations of Sema3a, Sec24b, and Megf8 in mouse models. They had conducted a three-generation, forward genetic screen to identify recessive mutations that affect the patterning of the peripheral nervous system and had identified Sema3A, Sec24B and MEGF8 genes as playing an important role in neuronal development. In order to study their role in detail, point mutations were chemically induced in these genes in order to obtain the respective mouse strains.
Looking for Partners: To license this material for research purposes
Stage of Development: Tangible Material
Data Availability: Animal data
Patent Status: None - Tangible material.
Publication(s)/Associated Cases: The Journal of Neuroscience. (2010). 30(16):5767–5775
Nature Cell Biology (2010). 12(1):41-48
Categories: Tangible material, research tool, mouse strain
Keywords: SEMA3A, SEC24B and MEGf8 mutations
