Novel Strategy to Preview Low Dose CT Images
JHU REF: C12995
Invention Novelty: The technology is a novel method to preview low dose x-ray and cone beam computed tomography images to predict the minimum radiation dose required to generate an image for clinical use.
Value Proposition:
Cone-beam computed tomography (CBCT) is used for several clinical imaging purposes, which often require multiple scans. In order to reduce exposure to radiation, the minimum dose needed to perform a particular imaging task is used. This method provides a way to generate a low dose preview image from previous scans of the patient to determine whether a given dose will be sufficient for a specific task. Advantages include:
- Accurately predicts images resulting from low radiation dose CBCT scans
- Reduces patient and physician exposure to radiation
Technical Details:
Johns Hopkins researchers imaged cadaver using CBCT at different radiation doses. Noise was then injected into the dataset and the resulting image was constructed using two reconstruction methods. The low dose preview images were then compared to actual CBCT images. Using both methods, the LDP images produced by both methods demonstrated a similar level of noise and other factors when compared to CBCT images for the whole dose range.
Looking for Partners: To develop and commercialize the technology as a digital x-ray imaging system to accurately simulate images produced by reduced radiation doses for clinical use.
Stage of Development: Pre-Clinical
Data Availability: prototype
Patent Status: pending
Publication(s)/Associated Cases: Wang AS et al. Med Phys. 2014 Jul;41(7):071915.
