Invention novelty:
This invention reveals an unexpected, novel kelch-like ECH-associated protein 1 (KEAP 1) mediated signaling pathway in renal development.
Value Proposition:
The Nrf2-Keap1 pathway has an important role in both acute kidney injury (AKI) and chronic kidney disease (CKD). This pathway has a key regulatory function on many antioxidant and stress pathways, including heme oxygenase. This technology identifies KEAP 1 as factor involved in cyst formation and hydronephrosis during kidney development, which is advantageous for:
• Studying kidney development
• The role of the KEAP 1 pathway in kidney repair and regeneration.
Technical Details:
Johns Hopkins researchers have discovered a novel role for KEAP1 mediated signaling pathway in renal development. They have identified that absence of KEAP1 in renal tubular epithelial cells significantly affects normal kidney development in a fashion consistent with hydronephrosis. Kidney epithelial cell specific Keap1-deficient (Ksp-Keap1-KO) mice were generated by crossing Ksp-Cre with Keap1 floxed (Keap1fl/fl) mice. A comprehensive histological examination along with detailed hematological, biochemical and urinary analysis was performed to evaluate these mice
Looking for Partners:
To develop & commercialize the technology as a research/discovery tool to aid in the development of therapeutics for acute kidney injury and chronic kidney disease.
Stage of Development: Tangible material
Data Availability: Animal Data
Publication(s)/Associated Cases: JHU: C13210, J Am Soc Nephrol. 2015 Dec;26(12):2989-3000
