TITLE
Overexpression of ntrk1 cDNA in the non tumorgenic breast epithelial cell line MCF-10A
JHU Ref. #
C13626
ABSTRACT
The overexpression of ntrk1 cDNA in the pIRESneo3 plasmid in human non-cancerous breast epithelial cell line MCF-10A. Ntrk1 is amplified in some breast cancers and MCF-10A is a non-cancerous breast cell model in which the ntrk1 overexpression phenotype can be characterized.
FEATURES
Johns Hopkins researchers Has overexpressed ntrk1 in non-cancerous breast epithelial cell line MCF-10A. This gene has never been overexpressed in human breast cell line that wasn’t tumorigenic, allowing for:
1. The novel characterization of the functional and phenotypic impact of this amplification on non-cancerous breast cells.
2. These overexpressed ntrk1 cDNA cell lines are useful for studying functional biology, drug sensitivity and other phenotypes in vitro.
STAGE OF DEVELOPMENT
Tangible material, ntrk1 cDNA MCF-10A cell line.
DISEASE INDICATION
Breast Cancer
ASSOCIATED PUBLICATIONS
- None -
