Human Enteroids

Case ID:
C14239
Invention Novelty:
This invention establishes human enteroids as nontransformed cell culture models to understand human intestinal physiology and pathophysiology and the epithelial response, including host restriction, cell type restriction, and virus-induced fluid secretion.
 
Value Proposition:
Johns Hopkins researchers have developed novel, cellularly diverse, and physiologically relevant epithelial cell cultures that recapitulate in vivo properties of gastrointestinal infections and allow the study of early molecular events during gastrointestinal infections. Additionally, drug therapies to prevent/treat gastrointestinal diseases can be tested in these physiologically active cultures.
 
Technical Details:
Johns Hopkins researchers have developed a bank of human enteroids or mini-intestines has been prepared with IRB approval from normal subjects and patients. These can be grown indefinitely as a cell culture model. They are used to study normal and disease related aspects of intestinal function.
 
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For Information, Contact:
Nakisha Holder
nickki@jhu.edu
410-614-0300
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