Human Enteroids

Invention Novelty:
This invention establishes human enteroids as nontransformed cell culture models to understand human intestinal physiology and pathophysiology and the epithelial response, including host restriction, cell type restriction, and virus-induced fluid secretion.
 
Value Proposition:
Johns Hopkins researchers have developed novel, cellularly diverse, and physiologically relevant epithelial cell cultures that recapitulate in vivo properties of gastrointestinal infections and allow the study of early molecular events during gastrointestinal infections. Additionally, drug therapies to prevent/treat gastrointestinal diseases can be tested in these physiologically active cultures.
 
Technical Details:
Johns Hopkins researchers have developed a bank of human enteroids or mini-intestines has been prepared with IRB approval from normal subjects and patients. These can be grown indefinitely as a cell culture model. They are used to study normal and disease related aspects of intestinal function.
 
Publication(s):

• J Biol Chem. 2016 Feb 19;291(8):3759-66.
• Journal of Virology. 201;  90(1), 43-56.
• CMGH Cellular and Molecular Gastroenterology and Hepatology. Volume 2, Issue 1, January 2016, Pages 48–62.e3
• Gastroenterology. 2016 Mar;150(3):638-649.

 
 
 
 

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