🔍
Microfluidic Settling Velocity Based Separation of Synthetic and Biological Particles
Case ID:
C11659
Report of Invention:
8/22/2011
Web Published:
2/24/2017
Novel Microfluidic Blood Fractionation Device
JHU REF: [C11659]
Invention novelty:
Separation of components of blood by microfluidic device without damaging its morphology.
Value Proposition
The proposed invention possesses several advantages over the current technologies employed for blood fractionation as follows:
Reduction in infrastructure costs and tediousness of blood fractionation procedures.
Unique design of the device which enables fractionation of blood into different components like RBCs, plasma etc. without the aid of external forces.
Minimally invasive technique thereby reducing the damage caused to the morphology and lifespan of the blood cells during the fractionation process.
Technical Details
Johns Hopkins University researchers have developed a device which consists of a microfluidic platform patterned with slanted rectangular grooves of 400 micron dimensions. The patterns are made of medically safe Polydimethylsiloxane (PDMS) using standard photolithography procedures. When blood is passed along the channels, it is continuously fractionated into different components like red blood cells, white blood cells and platelets based on their individual settling velocities. The settling velocity of a particle depends on its mass and flow rate, hence heavier particles are deflected by the grooves on the device while the lighter particles flow across the channels unimpeded. This principle forms the basis of the functioning of this device which also has applications in several fields like detection of floating tumor cells, bacterial cells and in physical separation processes.
Looking for Partners:
To develop & commercialize the technology as blood fractionation equipment or other uses such as:
Point of care (POC) diagnostics for tumor cell detection and bacterial contamination of food items.
Physical separation of particle suspensions in chemical processes.
Inkjet printing, electro-wetting and optoelectronics based devices.
Stage of Development
: Prototype
Data Availability:
Under NDA/CDA
Patent Status:
Provisional
Publication(s)/Associated Cases:
‘
Not at this time’
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
Microfluidic Settling Velocity Based Separation of Synthetic and Biological Particles
PCT: Patent Cooperation Treaty
United States
14/241,375
9,597,692
8/27/2012
3/21/2017
8/27/2032
Granted
Direct Link:
https://jhu.technologypublisher.com/technology/24246
Inventors:
Category(s):
Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Specimen Handling, Technology Classifications > Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Microfluidics,
Get custom alerts for techs in these categories/from these inventors:
Subscribe for JHTV Updates
For Information, Contact:
Vera Sampels
vsampel2@jhu.edu
410-614-0300
Save This Technology:
Bookmark this page
Download as PDF
JHTV Home
|
Search
|
Login/Subscribe
2017 - 2022 © Johns Hopkins Technology Ventures. All Rights Reserved. Powered by
Inteum