Human immunoglobulin purified from NMO-IgG positive patient plasma

Case ID:

C12575

Purified Human IgG Antibodies from Positive NMO- IgG Patient

JHU REF: [C12575]

Invention Novelty: This technology provides purified human IgG antibodies isolated from plasma cells from a Neuromyelitis Optica (NMO) positive patient.

Value Proposition: NMO or Devic’s disease is a rare inflammatory disease in the optic nerves, and spinal cord where specific disease-related antibodies trigger an autoimmune response in the body. To better understand these mechanisms, purified antibodies samples are needed but difficult to obtain due to the rarity of the disease and processing technique. This technology offers purified IgG antibodies which can be used as an investigative tool to learn more about the immunological dynamics in NMO. Other advantages include:

Purified samples enriched with NMO- IgG

Access to isolation and purification techniques to repeat in a variety of lab settings

Potential development of an improved diagnostic or pathogenic biomarker

Technical Details: Johns Hopkins researchers have purified human immunoglobulins (IgG) from the plasma cells in a patient that tested positive for NMO via a NMO- IgG serum immunoassay. These samples were obtained from plasmapheresis which removes plasma cells containing circulating antibodies associated with disease. This technology also include the methods for isolation and purification of the IgG component with enriched NMO-IgG to serve as tool to further study of human immune system responses to NMO.

Looking for Partners: To develop & commercialize the technology as a research tool for investigating human immunological mechanisms in patients with NMO.

Stage of Development: Ready for use

Data Availability: “Under CDA / NDA”

Patent Status: Tangible Material

Publication(s)/Associated Cases: BMC Neurology 2013, 13:104

Any data available?

Direct Link:

https://jhu.technologypublisher.com/technology/24287

Inventors:

Category(s):

Clinical and Disease Specializations, Clinical and Disease Specializations > Autoimmunity > Neuromyelitis Optica, Clinical and Disease Specializations > Inflammation > Chronic Inflammatory Diseases, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Ophthalmology > Optic Neuritis, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Blood & Tissue Samples, Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Immunology, Technology Classifications > Research Tools > Antibodies,

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For Information, Contact:

Nakisha Holder

nickki@jhu.edu

410-614-0300

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