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Parallelization of Fission and Fusion Operations for High Throughput Generation of Combinatorial Droplets
Case ID:
C12862
Report of Invention:
1/14/2014
Web Published:
2/24/2017
Recent research in digital microfluidics has burgeoned as droplets can function as miniaturized reactors in biological and chemical applications. Droplet microfluidic platforms boast the ability to generate many reactions within short time periods. However, most droplet platforms digitize samples into discrete droplets and are limited to the analysis of single samples under homogeneous probe conditions. Such platforms are incapable of addressing the needs of next generation applications which require large libraries of samples and probes. Examples include SNP analysis for crop improvement and genotyping required for identification of genes associated with common diseases. JHU researchers present a parallelized droplet-based platform for ondemand, combinatorial generation of nanoliter droplets. By parallelizing fission and fusion modules, throughput is increased by two orders of magnitude. With 32 Hz droplet generation, the projected throughput of this parallelized design is nearly 3 million sampleprobe droplets per day on a single device (with 4 replicates of 750 thousand different mixtures).This translates to 240 unique sample-probe mixtures with 4 replicates per minute.
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
SYSTEM AND DEVICE FOR HIGH THROUGHPUT GENERATION OF COMBINATORIAL DROPLETS AND METHODS OF USE
ORD: Ordinary Utility
United States
15/112,334
10,406,520
7/18/2016
9/10/2019
1/26/2035
Granted
Direct Link:
https://jhu.technologypublisher.com/technology/24322
Inventors:
Category(s):
Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Diagnostics, Technology Classifications > Research Tools > Microfluidics,
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For Information, Contact:
Vera Sampels
vsampel2@jhu.edu
410-614-0300
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