Therapies to Accelerate Resolution of Acute Lung Inflammation

Case ID:

C13113

Acute respiratory distress syndrome (ARDS) is a devastating inflammatory lung disease for which there are no effective targeted therapies. In experimental models of acute lung inflammation and injury, regulatory T cells (Tregs) orchestrate a pro-repair program; Tregs themselves are highly dependent on epigenetic mechanisms such as DNA hypomethylation. We found that systemically administering an inhibitor of DNA methylation (5-aza-2'-deoxycytidine [aka AZA and decitabine]) accelerates resolution of established lipopolysaccharide-induced lung injury in mice and requires Tregs for its pro-resolution effect. Moreover, AZA treatment of isolated Tregs increases their pro-repair function and allows a small number of Tregs to promote resolution of injury upon adoptive transfer to an injured animal.

Patent Information:

Title	App Type	Country	Serial No.	Patent No.	File Date	Issued Date	Expire Date	Patent Status
COMPOSITIONS AND METHODS TO ACCELERATE RESOLUTION OF ACUTE LUNG INFLAMMATION	PCT: Patent Cooperation Treaty	United States	15/542,380	10,905,706	7/7/2017	2/2/2021	3/9/2036	Granted
Compositions and Methods to Accelerate Resolution of Acute Lung Inflammation	DIV: Divisional	United States	17/139,665		12/31/2020			Pending

Direct Link:

https://jhu.technologypublisher.com/technology/24345

Inventors:

Category(s):

Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases > Acute Respiratory Distress Syndrome, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities > Repurposed Drugs,

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For Information, Contact:

Vera Sampels

vsampel2@jhu.edu

410-614-0300

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